Amicus Therapeutics Fighting Rare and Orphan Diseases with Relentless Research

Based in Cranbury, New Jersey, Amicus Therapeutics, is a biopharmaceutical company that develops therapeutics for rare and orphan diseases that are called lysosomal storage disorders.

Their platform, CHART, focuses on developing of enzyme replacement therapies with which to treat these lysosomal disorders. They are known in the biopharmaceutical industry as having an abundance of small molecule pharmacological chaperones.

As Amicus Therapeutics does not have the capability of manufacturing their products on their own they must rely on contracting it to other manufacturers, such as JCR Pharmaceutical and GlaxoSmithKline. They worked with them from 2010 to 2013 in investigating the coformulation and recombinant alpha-galactosidase for the advancement of migalastat monotherapy.

Amicus Therapeutics expanded its research facility from New Jersey, opening a second research site in San Diego, California in 2008 (Yahoo Finance). Then in 2010, they were able to collaborate with David Geffen at the School of Medicine,UCLA due to a grant received for $500,000 from the Michael J. Fox Foundation, the same year they received another grant for $210,300 from the Alzheimer’s Drug Discovery Foundation for pre-clinical research with Ichan School of Medicine, Mount Sinai, working with the Alzheimer’s Disease Research Center.

In 2013, a competitor of Amicus, Callidus Biopharma was acquired which gained them intellectual property and proprietary access for an enzyme replacement treatment for Pompe disease, an inherited Lysosomal Storage Disorder caused by the body not producing the enzyme acid alpha-glucosidase or GAA.

Their leading product, migalastat, which is used to treat persons with Fabry disease,a disease that can lead to progressive and irreversible organ damage. This disease will affect the nervous system as well as cardiac, renal and a multitude of other tissues. Migalastat is in the late stages of development.

Amicus has built a belief statement to cover their core values plus be a reminder for the reason they do every day what they do. Part of the belief is that they believe in the fight against these diseases, they strive to have the highest quality therapies for anyone with these diseases. They firmly believe in supporting the communities of these diseases and their families.
For job opportunities with Amicus Therapeutics visit Indeed or Twitter

Adam Milstein Has Been an Adept Advocate for Israel & the Jewish Culture, Making Him the Top Philanthropist

Adam Milstein has cut a niche in the real estate sector of the U.S. His firm, Hager Pacific Properties, manages properties worth billions of dollars across the country. Just as he has excelled in real estate, Adam is a well-known philanthropist. His generosity was recently honored as his name featured in the list of Philanthropists and Social Entrepreneurs Top 200.


Philanthropic Works


Adam and his wife actively run the Adam and Gila Milstein Family Foundation that invests in students from Israel living across the world, helping them learn about their Jewish culture. The foundation also helps them establish connections with Israel, their home country. Many students have passed through the organization, and it is evident that they have largely benefited. Adam has been keen in helping establish a good relationship between Israel and the United States. This is why he started the Israeli-American Council that works towards achieving that relationship. Adam also uses the council to influence the development of a foreign policy that will benefit Israel and the Jewish people at large. To further help the Jewish people learn their culture, he has made many publications concerning the heritage. Adam has not relented in emphasizing on the need to learn how to read and write in Hebrew. Adam is also a voice for the marginalized groups across the globe, and he has used every chance he gets to fight for them. Adam understands their pleas well, considering that his wife was a Moroccan immigrant to the United States. Adam Milstein does not lead from the desk; he gets himself actively involved with the charitable missions. This trait make Adam stand out from other philanthropists and real estate moguls

About Adam Milstein


Adam Milstein’s background education includes an MBA in Entrepreneurship from the reputable University Of Southern California. He holds an Industrial & Business Management degree certificate from the Israel Institute of Technology.

Adam Milstein heads a real estate company, Hager Pacific Properties, as the chief executive. His mandate is to implement the firm’s strategic plan. He also offers his guidance in the financing and accounting operations of the company.

Sawyer Howitt, Young Entrepreneur and Philanthropist

When you think of successful entrepreneurs, you usually think of someone older with years of experience. When someone like Sawyer Howitt comes along, it’s like a breath of fresh air and a welcome surprise. He was attending Lincoln High School in Portland, Oregon and has since graduated. Sawyer Howitt worked at RFID Checkout as a business strategy analyst from 2015 to 2016, and before then was in customer service with KURE Juice Bar. Sawyer Howitt is currently employed at The Meriwether Group as project manager.

His studies, experience in customer service, using innovative technology, and his intelligence have given him the tools necessary to be an entrepreneur. His father is Founder and CEO of The Meriwether Group, so Sawyer learned much from him. Sawyer’s job of project manager at The Meriwether Group has Sawyer advising on the changes to the structure of commerce when it applies to large and small business development. He understands the operations of a business and its financial needs, as well as appreciates the way a brand connects on so many levels and how it applies to the consumer. Sawyer Howitt takes on any tasks whether it is big or small and put his all into it. His enthusiasm and energy reflects in his work.

In addition to his work at The Meriwether Group, Sawyer also is a philanthropist. He has been a part of several charitable organizations that supports women’s rights and educational funding. He led international ethnic group studies, and helped conflicted young people. This is a young man that the business world should keep an eye on.